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Myrtenal Ameliorates Ischemic Brain Injury Diabetic and Non-Diabetic Rats.

Engin Korkmaz1, Asiye Beytur1, Yavuz Erden2

  • 1Faculty of Medicine, Department of Physiology, İnönü University, 44280, Malatya, Turkey.

Neurochemical Research
|December 17, 2025
PubMed
Summary

Myrtenal (Myrt) shows neuroprotective effects against ischemic stroke (IS) in rats, reducing damage and improving outcomes in both diabetic and non-diabetic models. This compound may offer a therapeutic strategy for IS patients with or without diabetes.

Keywords:
AktDiabetes mellitusIschemia reperfusion injuryIschemic strokeMyrtenalPI3K

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Ischemic stroke (IS) is a significant global health concern, leading to death and disability.
  • Diabetes mellitus exacerbates IS severity and increases mortality rates.
  • Identifying novel therapeutic agents for IS, especially those effective in diabetic individuals, is crucial.

Purpose of the Study:

  • To investigate the neuroprotective potential of Myrtenal (Myrt) in a rat model of ischemic stroke.
  • To evaluate Myrt's efficacy in both diabetic and non-diabetic conditions.
  • To elucidate the underlying molecular mechanisms of Myrt's neuroprotection.

Main Methods:

  • Sprague Dawley rats were pretreated with Myrt (40 mg/kg) for 28 days before inducing IS via middle cerebral artery occlusion.
  • Neurological deficits were assessed using behavioral tests.
  • Infarct volume, oxidative stress markers (MDA, SOD, CAT, GSH-Px), inflammatory cytokines (NLRP3, TNF-α, IL-6, IL-1β), and key signaling pathways (BDNF/TrkB, PI3K/Akt) were analyzed.

Main Results:

  • IS induced significant neurological deficits, increased infarct volume, oxidative stress, inflammation, and apoptosis, particularly in diabetic rats.
  • Myrt pretreatment significantly attenuated IS-induced pathological changes in both diabetic and non-diabetic rats.
  • Myrt administration upregulated neuroprotective pathways (BDNF/TrkB, PI3K/Akt) and reduced apoptosis markers.

Conclusions:

  • Myrtenal demonstrates significant neuroprotective effects against ischemic stroke in a rat model.
  • Myrt ameliorates IS-induced damage by mitigating oxidative stress, inflammation, and apoptosis.
  • The findings suggest Myrt's potential as a therapeutic agent for ischemic stroke, irrespective of diabetic status.