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Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...

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Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.

Zhuo Chen1, Chenhao Bai1, Fengyu Liu1

  • 1Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China.

Proceedings of the National Academy of Sciences of the United States of America
|December 17, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel "lab on an end" (LoE) microfluidic platform inspired by cilia. This acoustohydrodynamic system enables precise manipulation and processing for chemistry and biology research.

Keywords:
acoustohydrodynamicsdroplet manipulationmicromanipulationopen microfluidic devicessingle-cell operation

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Area of Science:

  • Microfluidics
  • Acoustics
  • Biotechnology

Background:

  • Microfluidics offers potential in chemistry, diagnostics, and biology but lacks widespread adoption.
  • Existing microfluidic systems face challenges in achieving continuous flow and multifunctional manipulation.
  • Biological systems, like cilia, provide models for efficient fluid dynamics.

Purpose of the Study:

  • To introduce an open microfluidic platform, "lab on an end" (LoE), for advanced micromanipulation.
  • To leverage acoustohydrodynamics for generating continuous flow and enabling diverse microscale operations.
  • To address the need for accessible, cost-effective, and integrated microfluidic solutions.

Main Methods:

  • Development of an open microfluidic platform utilizing an acoustohydrodynamic pillar array.
  • Employing acoustic radiation and frequency-dependent microstreaming (out-of-plane vortex and in-plane transmission flow).
  • Integration of micromanipulation, liquid operations, and cell processing onto a single acoustic end effector.

Main Results:

  • Demonstrated multifunctional micromanipulation and processing capabilities of the LoE platform.
  • Successful applications in embryo engineering, Caenorhabditis elegans phenotyping, and chemical reactions.
  • Showcased the platform's ability to integrate multiple sequential processes efficiently.

Conclusions:

  • The LoE platform offers an end-to-end solution for mainstream chemistry and biomedical research.
  • Its design facilitates breakthroughs in microfluidics by enabling high accessibility, ease of use, and low cost.
  • The platform has the potential to significantly advance fields requiring precise microscale control and analysis.