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Bench to Bedside: Translating Discoveries to Clinical Care in Kidney Disease

Katharine Epler1, Dana Y Fuhrman2, Sudarshan Hebbar3

  • 1UCSD and VA San Diego Healthcare System, San Diego, California, USA.

Nephron
|December 17, 2025
PubMed
Abstract

Insights

Acute kidney injury (AKI) presents complex challenges in prediction and treatment. This review highlights advancements in risk stratification, molecular phenotyping, diagnostics, and therapeutics to improve AKI patient outcomes.

Area of Science:

  • Nephrology
  • Translational Medicine
  • Biomarkers

Background:

  • Acute kidney injury (AKI) exhibits heterogeneous pathophysiology and repair mechanisms, complicating clinical outcome prediction.
  • Current treatment options for AKI are largely supportive, with limited success in translating preclinical findings to human subjects.
  • Translational research is crucial for advancing AKI therapies from bench to bedside.

Purpose of the Study:

  • To review cutting-edge translational work presented at the AKI & CRRT 2025 pre-conference symposium.
  • To guide the scientific community in addressing challenges in AKI research and treatment.
  • To summarize strategies for improving AKI diagnosis and therapy.

Main Methods:

  • Review of plenary session topics from a specialized AKI & CRRT 2025 symposium.
  • Focus on risk stratification, molecular phenotyping, diagnostics, and therapeutic targets in AKI.
  • Synthesis of current translational research in acute kidney injury.

Main Results:

  • Exploration of 'kidney fitness' as a concept for AKI risk stratification.
  • Characterization of molecular phenotypes to better understand AKI.
  • Discussion of improved diagnostics and novel therapeutic targets for AKI.
  • Identification of strategies to overcome translational barriers in AKI research.

Conclusions:

  • Advancements in understanding AKI heterogeneity are essential for clinical progress.
  • Improved diagnostics and targeted therapeutics hold promise for AKI management.
  • Translational efforts are key to developing effective AKI treatments and improving patient outcomes.
Keywords:
KidneyPhenotypeTranslation

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