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06:26
Analyzing Ex Vivo Metabolic Flux in Splenic and Cardiac Macrophages and Bone Marrow Monocytes
Published on: March 28, 2025
908
Immunometabolic insights into the foreign body response
Srinidhi Venkatesan1, Dauda L Mshelia2, Chima V Maduka1
1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Science Advances
|December 17, 2025
Summary
Immune cell energy differences drive chronic inflammation. Increased glucose consumption by these cells is a key factor in scar tissue development around medical implants.
Area of Science:
- Immunology
- Biomaterials Science
- Metabolic Research
Background:
- Chronic inflammation is a persistent immune response.
- Metabolic reprogramming of immune cells influences inflammatory processes.
- Biomaterial implantation can trigger foreign body responses and inflammation.
Purpose of the Study:
- To investigate the link between immune cell energy metabolism and inflammation.
- To determine the role of glucose uptake in scar tissue formation around implants.
Main Methods:
- Analysis of immune cell metabolic profiles.
- Assessment of glucose uptake in immune cells.
- Histological evaluation of tissue response to implanted materials.
Main Results:
- Significant variations in energy utilization exist among immune cells.
- Elevated glucose uptake by immune cells correlates with heightened inflammation.
- Higher glucose consumption is strongly associated with increased fibrotic encapsulation of implants.
Conclusions:
- Immune cell metabolic heterogeneity contributes to sustained inflammation.
- Targeting glucose metabolism in immune cells may mitigate implant-associated fibrosis.
- Understanding immune cell bioenergetics is crucial for improving biomaterial performance.
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