Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Growth hormone causes reversible fibrosis in muscle and fat: a study in patients with acromegaly.

European journal of endocrinology·2026
Same author

Assessment of body composition in active and controlled acromegaly by bioelectrical impedance analysis and dual-energy x-ray absorptiometry.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·2025
Same author

Pass/Fail Versus Tiered Grades and Academic Performance in Undergraduate Medical Education: Crossover Study.

JMIR medical education·2025
Same author

Titration and Treatment of Virtual Type 2 Diabetes Patients using an Adaptive Automated Insulin Delivery System.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

The Danish Nationwide osteoporosis cohort trials environment (NOCTE) - a DXA dataset for the 1900-1960 birth cohort.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2025
Same author

Symptom-driven co-existence of diabetic autonomic neuropathy, peripheral neuropathy, and painful neuropathy.

Acta diabetologica·2025
Same journal

Improving post-thyroidectomy care using a PTH and calcium-based algorithm.

European journal of endocrinology·2026
Same journal

Sampling variability and concordance between sequential and simultaneous adrenal venous sampling in primary aldosteronism subtype diagnosis.

European journal of endocrinology·2026
Same journal

Independent Clonal Evolution in Primary Pigmented Nodular Adrenocortical Disease: A Single-Patient Multi-Omics Study.

European journal of endocrinology·2026
Same journal

Twenty years of neurosurgical experience with Cushing's disease: surgical-strategies, endocrine outcomes and remission predictors in 346 patients.

European journal of endocrinology·2026
Same journal

Long-term Clinical Outcomes of Primary Adrenal Insufficiency Caused by Homozygous CYP11A1 p.R451W Variant.

European journal of endocrinology·2026
Same journal

Universal screening to detect hypothyroidism in pregnant women.

European journal of endocrinology·2026
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

7.2K

Rising burden of PRL-PitNETs: patterns across tumour sizes and incidentalomas.

Frederik Østergaard Klit1,2,3, Sara Faartoft Nørgård1,2, Anna-Sofie Dam Berrett1,2

  • 1Department of Endocrinology, Aalborg University Hospital, 9000 Aalborg, Denmark.

European Journal of Endocrinology
|December 17, 2025
PubMed
Summary
This summary is machine-generated.

Prolactin-secreting pituitary neuroendocrine tumours (PRL-PitNETs) are becoming more common, with increasing incidence in men and a rise in incidentalomas. This trend suggests a shift in disease characteristics and a growing healthcare burden.

Keywords:
epidemiologyhyperprolactinaemiaincidentalomamacroadenomaprolactinoma

More Related Videos

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.1K
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

11.4K

Related Experiment Videos

Last Updated: Jan 8, 2026

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

7.2K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.1K
Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

11.4K

Area of Science:

  • Endocrinology
  • Neuro-oncology
  • Epidemiology

Background:

  • Epidemiological data on prolactin-secreting pituitary neuroendocrine tumours (PRL-PitNETs) are limited and inconsistent.
  • PRL-PitNETs exhibit heterogeneity in age of onset, sex distribution, and tumor characteristics.

Purpose of the Study:

  • To investigate the temporal epidemiological trends of PRL-PitNETs.
  • To assess changes in prevalence, incidence, and patient demographics over time.

Main Methods:

  • A cohort study was conducted in the North Denmark Region (2017-2022) using ICD-10 coding and treatment data.
  • A systematic review and meta-analysis of published studies (PubMed, Embase) were performed.
  • Data analyzed included patient demographics, tumor size, and prolactin levels.

Main Results:

  • The cohort study revealed a 41% increase in PRL-PitNET prevalence from 2017-2022.
  • Meta-analysis of 15 studies (16,000 cases) showed increasing PRL-PitNET prevalence (41/100,000) and incidence (2.3/100,000 person-years).
  • A phenotypic shift was observed, with a higher proportion of men, macroprolactinomas, and incidentalomas over the past two decades.

Conclusions:

  • PRL-PitNETs demonstrate increasing prevalence, influenced by a rising incidence in men and incidentalomas.
  • These epidemiological shifts indicate a changing disease phenotype and an escalating clinical and healthcare demand.