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Enhancing data compatibility in an evolving landscape: Medical cannabis and polysubstance use protocols in the PhenX
Anne Buu1, Johannes Thrul2, Amanda Bunting3
1University of Texas Health Science Center at Houston, Houston, TX, USA.
Drug and Alcohol Dependence
|December 17, 2025
Summary
New measurement protocols for medical cannabis and polysubstance use are now available through the PhenX Toolkit. These standardized measures will improve research on the health effects of these substances.
Area of Science:
- Public Health
- Substance Use Research
- Measurement Science
Background:
- Increasing legalization of medical cannabis and polysubstance use necessitates standardized measurement tools.
- Existing PhenX Toolkit lacked measures for medical cannabis and polysubstance use.
- Standardized measures are crucial for studying population health effects.
Purpose of the Study:
- To identify and recommend measurement protocols for medical cannabis and polysubstance use.
- To expand the PhenX Toolkit with relevant substance use measures.
- To promote data compatibility and comparability in research.
Main Methods:
- A PhenX Working Group of experts convened in 2024.
- A consensus process was employed to select measurement protocols.
- The scientific community provided feedback on proposed recommendations.
Main Results:
- In 2025, 15 new protocols were released for the PhenX Toolkit.
- Protocols cover medical cannabis use (levels, products, motives, etc.) and polysubstance use patterns.
- New measures include biochemical validation and overdose risk assessment.
Conclusions:
- Adoption of these protocols will enhance comparability and reliability of research findings.
- Standardized measures facilitate evaluation of health effects and clinical guidance.
- Ongoing updates to measures will incorporate new scientific knowledge.
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