Related Experiment Video
Updated: Jan 8, 2026
Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
A balancing act: Evaluating the impact of a massive transfusion response team on early balanced resuscitation in
Annika Bickford Kay1, Sean Shughrou2, Sarah Majercik1
1Division of Trauma Services and Surgical Critical Care, Intermountain Medical Center, Murray, UT, USA.
Background:
Massive transfusion protocols (MTP) allow for rapid balanced transfusion. In non-traumatic hemorrhage, a hospital-wide MTP Response Team (MTRT) was created. We hypothesized that MTRT utilization would result in improved adherence to MTP.
Methods:
Adult non-traumatic hemorrhage patients with MTP order at a Level 1 trauma center January 2019-December 2023 were analyzed. MTPs managed without MTRT (NRT group) were compared to MTP with MTRT (MTRT group). Primary outcome was achievement of red blood cell (RBC) to fresh frozen plasma (FFP) ratio 1:1.
Results:
110 MTRT vs. 138 NRT analyzed. MTRT was associated with RBC:FFP ratio 1.1:1 vs NRT 1.5:1 (p = 0.004), shorter time to first RBC (10 vs 17 min, p = 0.0008) and less product wastage.
Conclusion:
For non-traumatic hemorrhage, MTRT was associated with more balanced RBC:FFP ratios, faster component transfusion, and less wastage. The clinical impact and scalability of this model across healthcare settings should be investigated.
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