Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

412
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
412
Genomics02:02

Genomics

39.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.5K
Depression: Overview01:18

Depression: Overview

747
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
747
Human Genetics01:28

Human Genetics

1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.

Molecular psychiatry·2026
Same author

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.

Nature genetics·2026
Same author

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.

Nature human behaviour·2026
Same author

The non-linear and linear effects of CYP2C19 metaboliser status on DNA methylation: a methylome-wide association study.

Clinical epigenetics·2026
Same author

Methylome-Wide Association Studies of Physical Injury Stratified by Depression Status Assesses Exposure by Diagnosis Effects in Oxytocin Signaling and Synaptic Plasticity.

Biological psychiatry global open science·2026
Same author

Age-dependent acceleration of structural brain aging in medication-free major depressive disorder linked to neuroanatomical phenotype findings from COORDINATE-MDD consortium.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jan 8, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K

Integrating Multi-Omics Summary Data Identifies Candidate Molecular Mechanisms for Major Depression.

Laurence Nisbet1, Yang Wu2, Mark Adams1

  • 1Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom.

Biological Psychiatry
|December 17, 2025
PubMed
Summary

This study used molecular data to find genes linked to Major Depression (MD). It identified new potential biomarkers and drug targets for MD, advancing our understanding of its genetic basis.

Keywords:
GeneticsMajor depressionMendelian randomizationMolecular mechanismsMulti-omicsPsychiatry

More Related Videos

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

796
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

Related Experiment Videos

Last Updated: Jan 8, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.0K
Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
07:58

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

796
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K

Area of Science:

  • Genetics
  • Psychiatry
  • Molecular Biology

Background:

  • Major Depression (MD) is a common psychiatric disorder with a known genetic component.
  • The biological mechanisms underlying MD are not well understood.
  • Identifying molecular biomarkers is crucial for understanding MD's etiology.

Purpose of the Study:

  • To identify molecular phenotypes associated with Major Depression (MD) using molecular quantitative trait loci (xQTL) data.
  • To discover novel genetic associations and potential biomarkers for MD.
  • To provide insights into the biomolecular mechanisms of MD.

Main Methods:

  • Utilized OPERA software to analyze genome-wide association study (GWAS) summary statistics and xQTL data.
  • Examined five molecular phenotypes: gene expression, DNA methylation, splicing variation, chromatin accessibility, and protein abundance.
  • Conducted analyses in both blood and brain tissues.

Main Results:

  • Identified 939 genes in blood and 607 genes in brain associated with MD.
  • Found enrichment of drug targets among the significant genes.
  • Highlighted 23 genes with robust associations across multiple molecular phenotypes, including novel associations like H6PD.

Conclusions:

  • The study identified promising new targets for MD biomarkers and drug development.
  • Expanded upon existing GWAS findings for MD, revealing novel genetic associations.
  • Recommended future research in cell and region-specific contexts for a more granular understanding.