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Related Experiment Video

Updated: Jan 8, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Linked data storage using DNA origami nanostructures.

Chenhao Zhang^1,2,3, Mo Xie^1,2,3, Lianhui Wang^1,2,3

¹State Key Laboratory for Flexible Electronics (LoFE), Nanjing University of Posts and Telecommunications, Nanjing, China.

Nature Communications

|December 17, 2025

Summary

This summary is machine-generated.

This study introduces a DNA origami nanostructure-enabled linked data storage (DONLDS) system for efficient data archiving. The DONLDS system enables rapid data access and modification, advancing DNA data storage capabilities.

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Area of Science:

Biotechnology
Nanotechnology
Data Storage

Background:

DNA-based storage offers a solution for archiving large volumes of cold data.
Future developments focus on enabling hot data storage with rapid access and modification.
Existing DNA storage methods face challenges in dynamic data management.

Purpose of the Study:

To develop a DNA origami nanostructure-enabled linked data storage (DONLDS) system.
To implement a linked list architecture for efficient data management.
To enable rapid random access and dynamic data modification in DNA storage.

Main Methods:

Utilizing distinct DNA origami shapes as nodes to store diverse data (English letters, numerals, Chinese characters).
Employing DNA strands as pointers at nanostructure edges to define data positions.
Using detachable DNA strands as instructions for dynamic linking and reversible detachment of pointers.

Main Results:

Achieved a high storage density of 222.22 Gbit/cm².
Demonstrated accurate data storage and retrieval through dynamic linking and detachment.
Enabled parallel data storage, insertion, and removal, eliminating full-structure traversal.

Conclusions:

The DONLDS system provides an adaptable and accurate solution for managing complex datasets.
This advancement moves DNA storage closer to meeting the demands of hot data.
Highlights the potential of DNA origami for next-generation data archiving and management.