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Updated: Jan 8, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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Left atrial-ventricular coupling index associated with new-onset atrial fibrillation in ST-segment elevation

Jiahua Liu1, Xinjia Du1, Jingfang Zhou1

  • 1Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

BMC Cardiovascular Disorders
|December 17, 2025
PubMed

Insights

The Left Atrial-Ventricular Coupling Index (LACI) is independently associated with new-onset atrial fibrillation (NOAF) in ST-segment elevation myocardial infarction (STEMI) patients. Incorporating LACI improves the identification of patients at higher risk for NOAF after PCI.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Electrophysiology

Background:

  • Management of new-onset atrial fibrillation (NOAF) in ST-segment elevation myocardial infarction (STEMI) patients presents clinical challenges.
  • The Left Atrial-Ventricular Coupling Index (LACI) is an emerging cardiovascular risk marker.
  • The association between LACI and NOAF in STEMI patients is not well-established.

Purpose of the Study:

  • To investigate the relationship between LACI, measured by cardiac magnetic resonance (CMR), and the occurrence of NOAF post-percutaneous coronary intervention (PCI) in STEMI patients.

Main Methods:

  • A retrospective, single-center study enrolled STEMI patients from September 2018 to December 2024 who underwent CMR.
  • LACI was calculated as the ratio of left atrial end-diastolic volume index to left ventricular end-diastolic volume index.
  • Multivariable logistic regression and ROC curve analyses were performed.

Main Results:

  • Of 553 STEMI patients, 46 developed NOAF.
  • LACI (OR=1.10), microvascular obstruction (OR=1.16), and heart rate (OR=1.03) were independent risk factors for NOAF.
  • LACI demonstrated good predictive performance (AUC=0.733) and significantly improved NOAF risk prediction models.

Conclusions:

  • LACI is an independent predictor of NOAF following PCI in STEMI patients.
  • Integrating LACI into risk assessment models enhances the identification of patients at elevated risk for NOAF.
Abstract

Keywords:
Cardiac magnetic resonanceLeft atrial-ventricular coupling indexNew-onset atrial fibrillationST-segment elevation myocardial infarction

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