Catheter‑related bloodstream infections and risk factors in infants hospitalized in neonatal intensive care units at Mogadishu, Somalia: two years of experience
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View abstract on PubMed
Summary
This summary is machine-generated.Catheter-related bloodstream infections (CRBSIs) affected 16.8% of neonates in Mogadishu. Low birth weight, preterm birth, and catheter type were significant risk factors for CRBSI prognosis.
Area Of Science
- Neonatal Intensive Care Unit (NICU) Medicine
- Infectious Diseases
- Epidemiology
Background
- Catheter-related bloodstream infections (CRBSIs) are a major cause of morbidity and mortality in neonates.
- Understanding CRBSI incidence, risk factors, and microbial profiles is crucial for improving neonatal outcomes.
Purpose Of The Study
- To determine the incidence of CRBSIs in a Mogadishu NICU.
- To identify risk factors, clinical characteristics, and microbial profiles associated with CRBSIs in neonates.
- To examine the influence of catheter type and birth weight on CRBSI outcomes.
Main Methods
- Retrospective observational study of 1,781 neonates admitted to the NICU between January 2022 and December 2024.
- Inclusion criteria based on 2009 IDSA guidelines for CRBSI diagnosis (paired blood/catheter tip cultures or differential time to positivity).
- Statistical analyses included Spearman's correlation and multivariable logistic regression to identify independent risk factors.
Main Results
- CRBSI incidence was 16.8% (300/1,781 neonates).
- Significant associations found between prognosis and birth weight, gestational age, catheter type, CRP levels, and culture sample type (p < 0.005).
- Klebsiella spp. was the most common pathogen, followed by E. coli and Candida spp. High antimicrobial resistance noted for Gram-negative and Gram-positive isolates.
Conclusions
- Low birth weight, preterm birth, catheter type, and elevated CRP levels are significant predictors of CRBSI prognosis in Mogadishu neonates.
- High antibiotic resistance rates highlight the need for enhanced antimicrobial stewardship and infection control in NICUs.
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