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Discovering Protein Interactions and Characterizing Protein Function Using HaloTag Technology
Published on: July 12, 2014
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Nanosystems Containing Proteins: From Fundamentals to Applications
Abhishek Baral1, Subhasish Roy2
1Department of Chemistry, Sister Nivedita University, DG Block, Action Area I, 1/2, Newtown, Kolkata, West Bengal, 700156, India.
Chemistry, an Asian Journal
|December 17, 2025
Summary
Protein-conjugated nanoparticles offer advanced nanomedicine solutions for diagnostics and drug delivery. This review details their preparation, applications, and biological interactions for theranostics.
Area of Science:
- Nanomedicine and Biomaterials Science
Background:
- Protein-conjugated nanoparticles (NPs) are crucial in nanobiomedicine for diagnostics, drug delivery, and probes.
- Protein-based nanomaterials show promise for theranostics due to enhanced bioabsorption and clearance.
Purpose of the Study:
- To review methods for creating stable protein-NP conjugates.
- To discuss applications of protein-NP conjugates in nanomedicine.
- To highlight the impact of NPs on protein structure and the significance of the protein-NP corona.
Main Methods:
- Review of covalent and non-covalent conjugation strategies.
- Analysis of protein conformation, folding, fibrillation, and aggregation upon NP interaction.
- Examination of the protein-NP corona's role in nanocomposite functionality.
Main Results:
- Various stable protein-NP conjugates can be prepared using covalent and non-covalent methods.
- NPs influence protein conformation, potentially affecting biological activity.
- The protein-NP corona is critical for the performance of nanocomposites.
Conclusions:
- Protein-conjugated NPs are versatile platforms for theranostics and other nanomedical applications.
- Understanding NP-protein interactions is essential for designing effective nanobiomaterials.
- Emerging nanomaterials like metal-free protein-NPs and nanoclusters expand therapeutic possibilities.
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