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FABP4 in lipid metabolism and the tumor microenvironment: mechanisms and therapeutic potential
Mengyun Wang1,2, Michael Hawanga1,2, Senlin Wan1,2
1Department of Gastrointestinal Surgery, the First Affiliated Yijishan Hospital of Wannan Medical College, No.2, Zheshan West Road, Wuhu, Anhui, 241001, China.
Abstract:
Fatty acid-binding protein 4 (FABP4), a key member of the fatty acid-binding protein family, is involved primarily in fatty acid transport, metabolic regulation, and inflammatory signaling. In recent years, numerous studies have shown that abnormal FABP4 expression in various tumors influences the metabolism of lipids and its metabolic products in tumors, significantly regulating tumor progression through processes such as oxidative stress, epithelial‒mesenchymal transition, angiogenesis, and the immune microenvironment. This review focuses on the role of FABP4 in tumors and systematically elucidates the specific mechanisms through which FABP4 regulates lipid metabolism and alters the tumor microenvironment. This review also provides an in-depth analysis of the complex network relationship between FABP4-mediated lipid metabolism and the tumor microenvironment and reveals the critical role of FABP4 in tumor occurrence, development, and metastasis, offering a new theoretical basis and potential targets for tumor therapy.
Insights
Fatty acid-binding protein 4 (FABP4) significantly impacts tumor progression by altering lipid metabolism and the tumor microenvironment. Understanding FABP4
Area of Science:
- Oncology
- Molecular Biology
- Metabolic Research
Background:
- Fatty acid-binding protein 4 (FABP4) is crucial for fatty acid transport and metabolic regulation.
- Abnormal FABP4 expression is increasingly linked to various tumor types and progression.
- FABP4 influences tumor progression via lipid metabolism, oxidative stress, EMT, angiogenesis, and immune microenvironment modulation.
Purpose of the Study:
- To review the multifaceted role of FABP4 in cancer.
- To elucidate the mechanisms by which FABP4 regulates lipid metabolism and the tumor microenvironment.
- To analyze the intricate relationship between FABP4, lipid metabolism, and the tumor microenvironment in cancer development and metastasis.
Main Methods:
- Systematic literature review focusing on FABP4 in cancer.
- Analysis of studies investigating FABP4's impact on tumor lipid metabolism.
- Examination of research on FABP4's influence on tumor microenvironment components.
Main Results:
- FABP4 dysregulation significantly affects tumor lipid metabolism and its products.
- FABP4 mediates tumor progression through oxidative stress, EMT, angiogenesis, and immune modulation.
- A complex interplay exists between FABP4-driven lipid metabolism and the tumor microenvironment.
Conclusions:
- FABP4 plays a critical role in tumor occurrence, development, and metastasis.
- FABP4 represents a potential therapeutic target for various cancers.
- Targeting FABP4-mediated lipid metabolism offers a novel strategy for cancer therapy.
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