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Economic Evaluation of Therapeutic Drug Monitoring and Precision Dosing in Pediatrics: A Short Communication

Víctor E Lechuga-Noa1,2, Guillermo Federico Taboada3, Paulo Cáceres Guido3

  • 1Cardiovascular Pharmacy, Instituto Nacional Cardiovascular-INCOR-EsSalud, Lima, Perú.

Therapeutic Drug Monitoring
|December 18, 2025
PubMed
Abstract

Keywords:
cost–benefit analysispediatricsprecision medicinetherapeutic drug monitoring

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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