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Updated: Jan 8, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
'Clip-Cycle' approaches to functionalised pyrrolidines, pyrrolizidines and indolizidines
Lee C Duff1, Selin Yilmaz1, Athanasia Agora1
1Department of Chemistry, University of York, YO10 5DD, Heslington, York, UK. william.unsworth@york.ac.uk.
Abstract:
The 'Clip-Cycle' approach is a versatile and modular synthetic method for the synthesis of aza-heterocycles via sequential cross metathesis and aza-Michael reactions. In this manuscript, a series of innovations to the 'Clip-Cycle' approach are reported. First, the asymmetric 'Clip-Cycle' syntheses of 2,5- and 3,5-pyrrolidines from chiral starting materials are reported for the first time, using a kinetic resolution method. A two-directional 'Clip-Cycle' approach for the synthesis of pyrrolizidines and indolizidines is then introduced.
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