Circ_0105487 Promotes the Metastasis of Triple-Negative Breast Cancer via Epithelial-Mesenchymal Transition

Circular RNAs (circRNAs) are recognized for their regulatory role in cancer progression and metastasis. However, their specific expression profiles and biological functions in breast cancer (BC) have not been fully elucidated. In the present study, we found that circ_0105487 exhibited upregulation in triple-negative breast cancer (TNBC) tumor tissues and cell lines. Moreover, its overexpression led to an enhancement in TNBC cell growth in vitro, whereas its knockdown had the opposite effect. Our in vivo experiments demonstrated that the knockdown of circ_0105487 inhibited lung metastasis in TNBC. Mechanistically, we found that circ_0105487 was associated with epithelial-mesenchymal transition and induced N-cadherin in TNBC cells. Rescue experiments showed that N-cadherin knockdown attenuated the effects of circ_0105487 overexpression on TNBC metastasis. In conclusion, circ_0105487 is an oncologic factor that promotes TNBC growth and metastasis and presents a novel therapeutic target for TNBC.