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Association Between Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Senile Patients with Coronary Artery

Jingwen Wu1, Jianyong Li2, Ping Ping3

  • 1Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Academician Chen Xiangmei of Hainan Province Kidney Diseases Research Team Innovation Center, Sanya, Hainan, People's Republic of China.

Clinical Interventions in Aging
|December 18, 2025
PubMed

Insights

The fibrinogen-to-albumin ratio (FAR) is linked to long-term mortality in elderly patients with coronary artery disease (CAD). A new model using FAR can help predict survival in these patients.

Area of Science:

  • Cardiology
  • Geriatrics
  • Biomarkers

Background:

  • Long-term mortality in senile patients with coronary artery disease (CAD) is a significant concern.
  • The combined impact of fibrinogen and albumin on mortality in this population requires further investigation.

Purpose of the Study:

  • To assess the association between the fibrinogen-to-albumin ratio (FAR) and 10-year mortality in elderly CAD patients.
  • To develop a predictive model for survival probability in this demographic.

Main Methods:

  • Analysis of data from 819 senile patients with CAD enrolled in the China Geriatric Cardiovascular Comorbidity Study.
  • Utilized multivariate Cox regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression for analysis and model development.

Main Results:

  • A higher FAR was significantly associated with shorter overall survival (p < 0.0001).
  • FAR was identified as a crucial factor affecting long-term mortality (HR = 37.75, p < 0.05).
  • A prognostic model incorporating age, hemoglobin, albumin, FAR, and lnNT-proBNP demonstrated good predictive power (AUC 0.838).

Conclusions:

  • The fibrinogen-to-albumin ratio (FAR) is independently associated with long-term mortality in senile patients with CAD.
  • A prognostic model based on FAR can assist in risk stratification for improved patient management.
Abstract

Keywords:
J-shaped relationshipcoronary artery diseasefibrinogen-to-albumin ratiolong-term mortalitysenile patients

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