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Published on: November 17, 2018
Modulation of STAT6 signaling for hepatoprotection
Emmanuel Somm1,2,3, Mahdi Rahman1,2,3, Ildiko Szanto1,2
1Service of Endocrinology, Diabetes and Metabolism, Department of Medicine, Geneva University Hospitals/University of Geneva, Geneva, Switzerland.
Abstract:
Signal transducer and activator of transcription (STAT) proteins are a family of seven transcription factors mediating various biological processes. STAT6 is classically known to regulate immune cell biology by transmitting signals from interleukin (IL)-4 and IL-13 into transcriptional activation of genes driving type 2 immunity. In orchestrating T helper lymphocytes and macrophages polarization, STAT6 plays a central role in the regulation of both cellular and humoral immunities. Several pathologies, including inflammatory disorders, autoimmune/allergic diseases, metabolic syndrome as well as cancer, are associated with a dysregulation of type 2 immunity related to inadequate expression and/or activity of STAT6. In the present review, following a brief introduction of STAT6 biology, we summarize the immunologic and physiological roles of STAT6 in the context of liver integrity as well as the potential roles of STAT6-mediated pathways in both hepatoprotection and liver pathophysiological mechanisms.
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