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Updated: Jan 8, 2026
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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
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Anatomical considerations in acromegalic patients: A multicentric cohort study
Elizabeth Escamilla-Chávez1, Marcos V Sangrador-Deitos2, Luis A Rodriguez-Hernandez3
1Department of Neurosurgery, Centro Médico ISSEMyM Toluca Arturo Montiel Rojas, Metepec, Estado de México, México.
Surgical Neurology International
|December 18, 2025
Summary
Mexican acromegalic patients exhibit distinct craniofacial and nasal anatomical variations. These subtle changes, including turbinate mucosa hypertrophy and enlarged ethmoid sinuses, may impact endoscopic pituitary surgery outcomes.
Area of Science:
- Endocrinology
- Neurosurgery
- Otolaryngology
Background:
- Craniofacial morphology changes due to elevated growth hormone (GH) differ across ethnic groups.
- International literature lacks specific data on Mexican populations regarding acromegaly and pituitary adenomas.
Purpose of the Study:
- To evaluate radiologic and endoscopic anatomical variations in Mexican acromegalic patients.
- To compare these variations with those found in patients with non-functioning pituitary adenomas (NFPA).
Main Methods:
- Studied 115 patients with GH-secreting pituitary adenomas (PA) or NFPA in Mexico.
- Analyzed hormonal levels, neuroimaging, and intraoperative endoscopy over one year.
- Focused on morphological changes specific to the Mexican population.
Main Results:
- GH-secreting macroadenomas (69.2%) correlated with turbinate mucosa hypertrophy (63.5%) and enlarged ethmoid sinuses (43%).
- Endoscopic findings showed occult ostium in <25% and carotid eminence identification in >75% of cases.
- Highest GH levels in macroadenomas did not significantly correlate with hidden ostium or turbinate hypertrophy.
Conclusions:
- Mexican acromegalic patients present subtle morphological changes.
- These variations can influence the safety and efficacy of the endonasal surgical approach.
- Impact is primarily noted in the nasal and sphenoid phases of surgery.
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