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Updated: May 2, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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The Silent Culprit: Drug-Induced Fever Associated With Trimethoprim-Sulfamethoxazole

Maria Lages1, Cristina Coelho2, Susana Cadinha2

  • 1Allergy and Clinical Immunology, Unidade Local de Saúde do Algarve, Faro, PRT.

Cureus
|December 18, 2025
PubMed

Insights

Drug-induced fever (DIF) is a challenging diagnosis, often mistaken for infection. This case highlights trimethoprim-sulfamethoxazole-induced fever, emphasizing the need for high suspicion and diagnostic testing.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Immunology

Background:

  • Drug-induced fever (DIF) poses diagnostic challenges, especially when co-occurring with infections.
  • The underlying mechanisms of DIF are not fully understood, complicating diagnosis and management.
  • Hallmarks of DIF include fever resolution upon drug cessation and recurrence upon re-exposure.
Keywords:
diagnostic challengesdrug provocation testdrug-induced feverhypersensitivity reactiontrimethoprim-sulfamethoxazole

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