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Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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Yeast as a tool for exploring disulfide-rich peptides

Kuok Yap1,2,3, Owen T Porth4,5, Jing Xie1

  • 1Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia.

FEMS Yeast Research
|December 18, 2025
PubMed
Summary

Yeast platforms enable efficient discovery and sustainable production of cyclic disulfide-rich peptides for drug development. These technologies advance peptide therapeutics through enhanced stability and large-scale biomanufacturing.

Keywords:
cyclic disulfide-rich peptidesenvironmentally sustainablehigh-throughputmicrofluidicsyeast expressionyeast-display

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