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Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution
Published on: January 16, 2017
The roles of RNA-binding proteins in ovarian aging
Hanyue Zhang1, Han Pan1, Tianying Zheng1
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, 450001, China.
Abstract:
The higher incidence of ovarian aging has led to a significant decline in the female fertility rate, raising social concerns about women's health. In recent years, the rapid development of RNA cross-linked proteomics technology has identified the role of RNA-binding proteins (RBPs) in ovarian aging. Ovarian aging disrupts the hypothalamic-pituitary-ovarian axis, resulting in aberrant hormone secretion, irregular menstrual cycles, oocyte apoptosis, and abnormal embryonic development. Given this, we have compiled the role of RNA-binding proteins in ovarian aging and further explored how different ovarian RBPs promote apoptosis and serve as therapeutic targets. We aim to analyze the effects of RNA-binding proteins on ovarian function to provide more explicit ideas for delaying ovarian aging and treating ovarian diseases.
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