Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.6K
Prosopagnosia01:24

Prosopagnosia

666
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
666
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

928
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
928

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Visual Acuity Outcomes in Socioeconomically Disadvantaged Patients With Vitreous Hemorrhage Resulting From Proliferative Diabetic Retinopathy Treated at a County Hospital.

Journal of vitreoretinal diseases·2026
Same author

Optic Atrophy in Wolfram Syndrome Type 1: A Retrospective Analysis of Visual Outcomes and Biomarker Correlates.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026
Same author

Acute Orbital Inflammatory Syndrome and Vision Loss After Aminobisphosphonate Infusion.

Neuro-ophthalmology (Aeolus Press)·2026
Same author

Autoimmune neuro-ophthalmic disorders: pathophysiologic mechanisms and targeted biologic therapies.

Expert opinion on biological therapy·2025
Same author

Approach to Diplopia.

Continuum (Minneapolis, Minn.)·2025
Same author

Assessment of the Quality, Accountability, and Readability of Online Patient Education Materials for Optic Neuritis.

Neuro-ophthalmology (Aeolus Press)·2024
Same journal

Concurrence of Inherited Nuclear and Mitochondrial DNA Optic Neuropathies.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026
Same journal

Aspergillus-Infiltrated Optic Nerve Sheath Meningioma in Immunocompetent Host Mimicking Optic Neuritis.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026
Same journal

Progression of Vitreous Detachment Leading to Exacerbation of Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026
Same journal

Characterizing the Role of Ophthalmologists in the Care of Patients With Suspected Giant Cell Arteritis at an Academic Medical Center.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026
Same journal

Optic Disc Drusen Is Frequently Not Reported on Computed Tomography Scans Performed for Other Reasons.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026
Same journal

Dorsal Midbrain Syndrome Due to Complicated Posterior Reversible Encephalopathy Syndrome.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2026
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.9K

Optic Atrophy Predominant WFS1 Disorder-A Case-Control Study.

Nicholas R Levergood1, Melissa W Ko, Katelyn K Payne

  • 1Departments of Ophthalmology (NRL, MWK, DDM), Neurology (MWK, KKP, DDM), Neurosurgery (MWK, DDM), and Medical and Molecular Genetics (KKP), Indiana University School of Medicine, Indianapolis, Indiana.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|December 18, 2025
PubMed
Summary
This summary is machine-generated.

Wolfram syndrome type 1 (WS1) can present with milder vision loss and isolated optic atrophy in adults. This study highlights arcuate visual field defects as a key indicator for WS1, distinct from other optic atrophy syndromes.

More Related Videos

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.1K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K

Related Experiment Videos

Last Updated: Jan 8, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.9K
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

4.1K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K

Area of Science:

  • Ophthalmology
  • Neurogenetics
  • Rare Diseases

Background:

  • Wolfram syndrome type 1 (WS1), also known as DIDMOAD syndrome, is a rare neurodegenerative disorder caused by WFS1 gene mutations.
  • Isolated adult-onset optic atrophy (OA) with milder phenotypes in WS1 is uncommon, typically linked to biallelic autosomal recessive mutations.
  • This study describes seven patients with pauci-syndromic WS1 presenting with adult-onset OA.

Purpose of the Study:

  • To describe a cohort of patients with pauci-syndromic Wolfram syndrome type 1 (WS1) presenting with adult-onset optic atrophy (OA).
  • To compare visual function parameters in WS1 patients with those in other OA-predominant syndromes.
  • To expand the understanding of the clinical spectrum of WS1 and the role of WFS1 mutations in vision loss.

Main Methods:

  • Retrospective review of patients with OA secondary to mutations in OPA1, WFS1, POLG, or Leber hereditary optic neuropathy (LHON), and other genetic causes.
  • Exclusion of patients with confounding causes of vision loss or non-genetic causes of OA.
  • Analysis of automated visual fields (AVF), optical coherence tomography (OCT) of ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (RNFL), and visual acuity (logMAR).

Main Results:

  • Patients with WS1 exhibited significantly later symptom onset and delayed presentation compared to other OA syndromes.
  • WS1 patients were more likely to present with arcuate scotomas, unlike LHON and OPA1 mutations which commonly presented with central scotomas or blind spot enlargement.
  • WS1 diagnosis was not significantly associated with specific RNFL or GCC thinning patterns, whereas ADOA showed the most peripapillary RNFL thinning.

Conclusions:

  • The WS1 cohort demonstrated milder vision loss and fewer syndromic features, suggesting an alternative, milder phenotype associated with WFS1 mutations.
  • Arcuate visual field defects and trends toward superior/inferior peripapillary RNFL thinning are significant associations in WS1 patients.
  • Clinicians should consider Wolfram syndrome in adult-onset, symmetric, near-isolated OA, particularly with arcuate field defects.