Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

250
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
250
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

231
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
231

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drug selection for inner ear therapy.

Frontiers in pharmacology·2024
Same author

Noise as an Extrinsic Variable in the Animal Research Facility.

Journal of the American Association for Laboratory Animal Science : JAALAS·2024
Same author

A Guinea Pig Model Suggests That Objective Assessment of Acoustic Hearing Preservation in Human Ears With Cochlear Implants Is Confounded by Shifts in the Spatial Origin of Acoustically Evoked Potential Measurements Along the Cochlear Length.

Ear and hearing·2024
Same author

CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear.

Hearing research·2021
Same author

Reducing Auditory Nerve Excitability by Acute Antagonism of Ca<sup>2+</sup>-Permeable AMPA Receptors.

Frontiers in synaptic neuroscience·2021
Same author

Improved Speech Intelligibility in Subjects With Stable Sensorineural Hearing Loss Following Intratympanic Dosing of FX-322 in a Phase 1b Study.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2021

Related Experiment Video

Updated: Jan 8, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

13.9K

Dexamethasone Dosing of Human Perilymph Compared for Common Delivery Protocols Using Inner Ear Simulations.

Alec N Salt1, Jeremy G Turner2

  • 1Turner Scientific, Jacksonville, Illinois, USA, asalt@turnerscientific.com.

Audiology & Neuro-Otology
|December 18, 2025
PubMed
Summary
This summary is machine-generated.

Cochlear implants offer the most efficient dexamethasone delivery for inner ear conditions, achieving therapeutic levels with minimal systemic exposure. Other methods like intratympanic injections show varied effectiveness and potential side effects.

Keywords:
CochleaCochlear implantDexamethasoneIntratympanic drugMeniere’s diseaseSudden sensorineural hearing loss

More Related Videos

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
06:55

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus

Published on: February 27, 2018

9.1K
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.9K

Related Experiment Videos

Last Updated: Jan 8, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

13.9K
A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
06:55

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus

Published on: February 27, 2018

9.1K
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.9K

Area of Science:

  • Otolaryngology
  • Pharmacokinetics
  • Biomedical Engineering

Background:

  • Local dexamethasone therapy is crucial for inner ear disorders like Meniere's disease.
  • Dexamethasone aids cochlear implantation by reducing electrode impedance and fibrous tissue.
  • Varied formulations complicate comparison of dexamethasone dosing levels.

Purpose of the Study:

  • To quantitatively compare dexamethasone delivery methods using simulation.
  • To assess perilymph and plasma dexamethasone levels for different dosing approaches.
  • To identify the most efficient and safest dexamethasone delivery protocols.

Main Methods:

  • Utilized FluidSim cochlear fluids simulation program.
  • Calculated perilymph and plasma dexamethasone levels for various clinical dosing strategies.
  • Employed identical pharmacokinetic parameters for perilymph and plasma.

Main Results:

  • All simulated protocols achieved therapeutic perilymph concentrations, but with different time courses.
  • Some protocols resulted in systemic plasma concentrations exceeding therapeutic levels, increasing side effect risk.
  • Cochlear implants demonstrated the most efficient delivery with minimal systemic impact.

Conclusions:

  • Simulation enables quantitative comparison of dexamethasone delivery protocols.
  • Cochlear implants provide superior dexamethasone dosing efficiency in the cochlea.
  • Spiral Therapeutics SPT-2101 and conventional intratympanic dexamethasone phosphate show distinct systemic exposure profiles.