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Related Experiment Video

Updated: Jan 8, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

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MoEGAD: A Mixture-of-Experts Framework With Pseudo-Anomaly Generation for Graph-Level Anomaly Detection.

Jinyu Cai, Yunhe Zhang, Pengyang Wang

    IEEE Transactions on Pattern Analysis and Machine Intelligence
    |December 18, 2025
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces MoEGAD, a novel framework for graph-level anomaly detection (GLAD) that addresses the challenge of limited labeled anomalies. MoEGAD effectively generates pseudo-anomalous graphs and utilizes a mixture of experts (MoE) for improved detection across various GLAD tasks.

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    Last Updated: Jan 8, 2026

    Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
    05:47

    Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

    Published on: June 13, 2025

    1.2K

    Area of Science:

    • Artificial Intelligence
    • Machine Learning
    • Data Mining

    Background:

    • Graph-level anomaly detection (GLAD) identifies outlier graphs but struggles with scarce labeled anomalies.
    • Limited anomaly diversity hinders robust decision boundary learning in semi-supervised GLAD.
    • Multi-task graph anomaly detection remains an underexplored but crucial area.

    Purpose of the Study:

    • To propose MoEGAD, a novel framework for graph-level anomaly detection (GLAD).
    • To address the challenges of limited labeled anomalies and enhance multi-task GLAD capabilities.
    • To leverage a mixture of experts (MoE) architecture for improved GLAD performance.

    Main Methods:

    • An iterative anomalous graph generation module creates pseudo-anomalies for training.
    • An early stopping mechanism ensures generated anomalies are sufficiently dissimilar from normal graphs.
    • A latent MoE module with expert and gating networks enables cross-task adaptability.

    Main Results:

    • MoEGAD significantly outperforms state-of-the-art GLAD baselines in experiments.
    • The framework demonstrates effectiveness across single-task, large-scale, and multi-task scenarios.
    • The proposed MoE architecture shows promise for advancing GLAD research.

    Conclusions:

    • MoEGAD offers a robust solution for GLAD, particularly in low-data regimes.
    • The framework's adaptability makes it suitable for diverse and complex GLAD problems.
    • This work pioneers the application of MoE architectures in graph-level anomaly detection.