Reply to: Improving the Clinical Interpretability of Functional Drug Screens: A Suggestion for Standardized Clinical

Wee Lee Chan1, Masturah Bte Mohd Abdul Rashid1, Rui Xue Lee1

  • 1Wee Lee Chan, MD, PhD, MRCP, Department of Haematology-Oncology, National University Health System, Singapore, Singapore, NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore; Masturah Bte Mohd Abdul Rashid, PhD, Kyan Technologies Pte Ltd, Singapore, Singapore; Rui Xue Lee, BSc (Hons), Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Sanjay de Mel, MBBS, MRCP, FRCPath, Department of Haematology-Oncology, National University Health System, Singapore, Singapore, NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore; Edward Kai-Hua Chow, PhD, NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore, Kyan Technologies Pte Ltd, Singapore, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, N.1 Institute for Health, National University of Singapore, Singapore, Singapore, Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; and Anand D. Jeyasekharan, PhD, MRCP, MBBS, Department of Haematology-Oncology, National University Health System, Singapore, Singapore, NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

JCO Precision Oncology
|December 18, 2025
PubMed
Abstract

No abstract available in PubMed .

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
653
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
309
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
133
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.5K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
169