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Updated: Jan 8, 2026
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Tuberculosis transmission in an Australian healthcare setting: lessons learnt from a coordinated public health
Tasnim Hasan1,2, Martin Plymoth3, Evan Ulbricht4
1Department of Infectious Diseases, Western Sydney Local Health District, Blacktown Hospital, Blacktown Road, Blacktown, Sydney 2148, NSW, Australia.
Objectives And Importance Of Study:
Tuberculosis (TB) remains a global public health concern. In Australia, TB incidence is low, but remains elevated among overseas-born individuals. This study investigates a TB cluster in a non-clinical hospital setting during the COVID-19 pandemic, highlighting transmission dynamics and the public health response.
Methods:
A retrospective observational study was conducted using medical records and epidemiological contact tracing data within a tertiary hospital in New South Wales, Australia. Three screening rounds targeted office contacts in different air-conditioning zones. Whole genome sequencing was used to assess Mycobacterium tuberculosis isolates.
Results:
Five secondary cases of TB disease were identified following exposure to the index case, a non-clinical hospital employee with cavitating pulmonary TB. Among 233 identified contacts, 117 completed screening. Initially screened high-risk contacts (n = 31) had high rates of TB disease (n = 4; 12.9%) and newly detected interferon gamma release assay-positivity (n = 14; 45.1%), with lower rates in broader screening. Transmission likely occurred via prolonged office exposure. Whole genome sequencing linked a sixth TB case in a clinical healthcare worker to the cluster, with 26 secondary contacts screened.
Conclusion:
This study underscores the potential for highly infectious TB transmission within Australian healthcare settings. Timely contact tracing, genomic surveillance, and pre-employment screening are essential for effective prevention and control.
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