Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

5.2K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
5.2K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England)·2026
Same author

Co-development of a protocol for a randomised controlled feasibility trial of CIRCuiTS™ cognitive remediation therapy for people with multiple sclerosis.

Pilot and feasibility studies·2026
Same author

Rational sadness in neurological disease.

Practical neurology·2026
Same author

Genetic Determinants of Multiple Sclerosis Susceptibility in People From Diverse Ancestral Backgrounds.

Neurology·2026
Same author

Recurrence of HIV-associated cryptococcal meningitis in pregnancy and the post-partum period.

International journal of STD & AIDS·2026
Same author

Late Lyme neuroborreliosis presenting with tremor and gait impairment.

Practical neurology·2026

Related Experiment Video

Updated: Jan 8, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

11.9K

Neurosyphilis-related myelitis.

Milo Patrick Delaney1, Shiran Ajith Paranavitane2, Larissa Mulka3

  • 1Neurology, King's College Hospital NHS Foundation Trust, London, England, UK milo.delaney@nhs.net.

Practical Neurology
|December 18, 2025
PubMed
Summary

Neurosyphilis, a rare cause of myelitis, can present as a hyperacute cord syndrome. Prompt diagnosis and treatment with antibiotics and steroids led to a sustained recovery in a young man with this rare neurological complication.

Keywords:
INFECTIOUS DISEASESMYELOPATHYNEURORADIOLOGY

More Related Videos

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.1K
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

10.0K

Related Experiment Videos

Last Updated: Jan 8, 2026

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

11.9K
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

5.1K
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

10.0K

Area of Science:

  • Neurology
  • Infectious Diseases
  • Spinal Cord Medicine

Background:

  • Syphilis is a complex infectious disease with diverse neurological manifestations.
  • Myelitis is an uncommon but serious neurological complication of syphilis.
  • Hyperacute cord syndromes require rapid diagnosis and intervention.

Purpose of the Study:

  • To report a rare case of neurosyphilis presenting as myelitis.
  • To highlight the diagnostic challenges and clinical features of syphilitic myelitis.
  • To emphasize the importance of considering neurosyphilis in acute myelopathy.

Main Methods:

  • Case report of a 29-year-old male with sudden onset paraplegia.
  • Clinical examination revealed flaccid paraplegia with a specific sensory level.
  • Spinal MRI demonstrated longitudinally extensive myelitis with characteristic imaging findings.
  • Diagnostic confirmation through positive syphilis serology in serum and cerebrospinal fluid.

Main Results:

  • The patient presented with sudden bilateral leg weakness, back pain, and urinary retention.
  • Spinal MRI revealed longitudinally extensive myelitis with 'candle guttering' and 'flip-flop' signs.
  • Syphilis serology was positive in both serum and cerebrospinal fluid.
  • A dramatic and sustained response to corticosteroids and antimicrobial therapy was observed.

Conclusions:

  • Neurosyphilis should be considered in the differential diagnosis of hyperacute myelitis.
  • Early diagnosis and treatment are crucial for favorable outcomes in syphilitic myelitis.
  • The characteristic MRI findings can aid in the diagnosis of this rare condition.