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Related Experiment Video

Updated: Jan 8, 2026

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival.

Stephen A Goutman^1,2, David G Stouffer³, Dae-Gyu Jang^1,2

¹Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.

Annals of Clinical and Translational Neurology

|December 18, 2025

Summary

This summary is machine-generated.

Sex hormones influence amyotrophic lateral sclerosis (ALS) risk and survival. Higher levels of certain androgens and estrogens were linked to increased ALS odds, particularly in females, and shorter survival times.

Keywords:

11‐hydroxyandrostenedione 11‐keto‐ALS androestenedione estradiol estrogen estrone sex hormones steroids testosterone

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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

Published on: March 17, 2012

Area of Science:

Endocrinology
Neurology
Epidemiology

Background:

Amyotrophic lateral sclerosis (ALS) incidence and progression exhibit sex-based differences.
Sex hormones are hypothesized to modulate ALS risk and clinical course.
Understanding these hormonal influences is crucial for targeted therapeutic strategies.

Purpose of the Study:

To investigate the association between plasma sex hormone levels and the odds of developing ALS.
To examine the relationship between sex hormone concentrations and survival duration in ALS patients.

Main Methods:

A case-control study was conducted involving 131 female and 189 male ALS patients, and 138 female and 150 male controls.
Plasma levels of biologically active sex hormones were measured.
Statistical analyses were performed to assess the association between hormone levels, ALS odds, and survival.

Main Results:

Elevated 11-ketotestosterone levels correlated with increased odds of ALS.
In females, higher levels of estrone, androstenedione, and 11-hydroxyandrostenedione were associated with greater ALS odds.
Higher estrone and estradiol levels in females predicted a shorter survival time.

Conclusions:

Sex hormones, including androgens and estrogens, play a significant role in the pathogenesis and progression of ALS.
Specific hormone profiles may serve as biomarkers for ALS risk and prognosis.
Further research is warranted to explore the therapeutic potential of modulating sex hormone levels in ALS management.