P16 Effect of moisturisers on allergen-induced inflammation and skin barrier
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View abstract on PubMed
Summary
This summary is machine-generated.Some moisturizers may weaken the skin barrier and increase allergic reactions to common allergens like house dust mites. This suggests a potential link between emollient use and the development of atopic diseases.
Area Of Science
- Dermatology
- Allergology
- Skin Barrier Research
Background
- Emerging evidence questions the protective role of moisturizers in preventing atopic dermatitis (AD) in infants.
- Moisturizers may increase the risk of allergic sensitization.
- Emollient vehicles can influence the penetration of active substances into the skin, impacting sensitization to environmental allergens.
Purpose Of The Study
- To investigate the impact of regular emollient use on skin reactions to house dust mite allergens.
- To assess how different emollients affect epicutaneous sensitization.
Main Methods
- An observer-blind study involving 40 adults with known house dust mite sensitization.
- Participants applied olive oil (OO), coconut oil (CO), or a basic emollient cream (EC) to their forearms for 4 weeks, with a no-treatment control (NTC) area.
- Skin barrier integrity was measured using trans-epidermal water loss (TEWL), and atopy patch tests (APT) were conducted.
Main Results
- All tested treatments (OO, CO, EC) significantly reduced skin barrier integrity, indicated by increased TEWL compared to the NTC.
- The emollient cream (EC) showed the strongest potentiation of atopy patch test reactions, followed by olive oil and coconut oil, compared to the no-treatment control.
Conclusions
- Certain moisturizers can compromise skin barrier function and enhance allergic responses to skin-contact allergens.
- Further research is needed to elucidate the mechanisms behind these effects and the role of moisturizers in the pathogenesis of atopic diseases.
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