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Sirtuin 2 Regulates Histone Glycation as a Semi-deglycase

Huapeng Li1,2, Yvonne Ritsema1,2, Zeng Lin1,2

  • 1Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.

Biochemistry
|December 19, 2025
PubMed
Summary

Sirtuin 2 (SIRT2) acts as a semi-deglycase, removing acids from modified histones. This enzyme, with DJ-1, helps prevent cell damage from methylglyoxal (MGO) and glyoxal (GO) in cancer.

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