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Updated: Jan 8, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
Published on: May 12, 2023
Levothyroxine suppression therapy improves maternal and neonatal outcomes in pregnancy after thyroidectomy for
Pingfa Gao1, Lyuping Hu2, Songzhou Lu2
1Department of Thyroid and Breast Surgery, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences Shanghai 202150, China.
Objectives:
To evaluate the efficacy of levothyroxine (L-T4) suppression therapy in women with a history of differentiated thyroid carcinoma (DTC), focusing on pregnancy outcome after thyroidectomy.
Methods:
This retrospective study included 300 pregnancies in women with previous DTC surgery. Participants were divided into an experimental group (n=187) receiving L-T4 doses adjusted based on thyroid-stimulating hormone (TSH) levels and a control group (n=113) following a fixed low-dose L-T4 regimen. We assessed various outcomes, including biochemical values (TSH dynamics, lipid profile, folic acid [FA] levels), obstetric measures (placental function, pregnancy complications), and neonatal outcomes.
Results:
The experimental group showed consistently lower TSH levels throughout pregnancy and experienced fewer pregnancy and neonatal complications compared to the control group (all P<0.05). Additionally, the experimental group demonstrated significant improvements in lipid profiles, FA levels, and placental function(all P<0.05).
Conclusions:
TSH-adjusted L-T4 therapy in pregnant women post-DTC thyroidectomy results in better maternal and neonatal outcomes compared to a fixed low-dose L-T4 regimen. This approach optimizes TSH stability, improves lipid and FA profiles, and enhances placental function, leading to improved overall outcomes for both the mother and child.
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