Treatment outcomes and determinants of combined hemodialysis-hemoperfusion therapy in chronic glomerulonephritis

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Xiaotong Yuan1,2, Caixiang Zhang1,2

  • 1Department of Nephrology, Shanxi Provincial People's Hospital Taiyuan 030012, Shanxi, China.

American Journal of Translational Research
|December 19, 2025
PubMed

Insights

Combined hemodialysis (HD) and hemoperfusion (HP) therapy significantly improves outcomes in chronic glomerulonephritis (CGN) patients compared to HP alone. This approach enhances bone metabolism and renal function while reducing toxins and inflammation.

Area of Science:

  • Nephrology
  • Renal Medicine
  • Internal Medicine

Background:

  • Chronic glomerulonephritis (CGN) poses significant challenges in managing bone and mineral metabolism disorders.
  • Serum parathyroid hormone (PTH), phosphorus (P), and calcium (Ca) levels are critical indicators of disease progression and treatment efficacy in CGN patients.

Purpose of the Study:

  • To evaluate the therapeutic efficacy of combined hemodialysis (HD) and hemoperfusion (HP) versus HP monotherapy in CGN patients.
  • To assess the impact of combined HD and HP on bone metabolism indices (PTH, P, Ca), renal function, inflammation, and quality of life.

Main Methods:

  • Retrospective analysis of 118 CGN patients treated between May 2022 and May 2024.
  • Patients were divided into HP group (n=52) and HD+HP group (n=66).
  • Comparison of clinical efficacy, bone metabolism, renal function, inflammatory markers, hemorheology, coagulation, uremic toxins, adverse events, and quality of life (SF-36).

Main Results:

  • The HD+HP group demonstrated a higher total effective rate (89.39%) compared to the HP group (73.08%).
  • HD+HP significantly reduced PTH, P, 24 h urinary protein, BUN, SCr, inflammatory markers, and uremic toxins.
  • HD+HP increased Ca, eGFR, t-PA, and SF-36 scores, with comparable adverse event rates.

Conclusions:

  • Combined HD and HP therapy offers superior therapeutic and biochemical benefits over HP monotherapy for CGN patients.
  • Disease duration >5 years and HP monotherapy are independent predictors of poor therapeutic response.
Abstract

Keywords:
Chronic glomerulonephritiscalciumhemodialysishemoperfusionparathyroid hormonephosphorus

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