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Related Concept Videos

Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

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Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
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Related Experiment Video

Updated: Jan 8, 2026

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
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Activation Map-Guided Ablation for Persistent Atrial Fibrillation Using Rhythmia Mapping System.

Yosuke Murase1, Yasuya Inden2, Yasuhiro Ogawa1

  • 1Department of Cardiology Komaki City Hospital Komaki Aichi Japan.

Journal of Arrhythmia
|December 19, 2025
PubMed
Summary
This summary is machine-generated.

Activation map-guided ablation for atrial fibrillation (AF) is more successful in patients with smaller left atrial volume and organized electrogram patterns. These factors predict lower arrhythmia recurrence after the procedure.

Keywords:
activation mapcatheter ablationleft atrial volumeorganized atrial electrogram patternpersistent atrial fibrillation

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Creating accurate activation maps during atrial fibrillation (AF) presents significant challenges.
  • Effective ablation strategies for persistent AF are crucial for improving patient outcomes.

Purpose of the Study:

  • To evaluate the effectiveness of activation map-guided ablation for persistent AF.
  • To identify predictors of successful ablation and lower arrhythmia recurrence.

Main Methods:

  • Activation map-guided AF ablation was performed in 29 persistent AF patients.
  • The Rhythmia mapping system was utilized for detailed electrophysiological mapping.
  • Left atrial volume (LAV) and ratio of organized atrial electrogram pattern (ROAE) were assessed.

Main Results:

  • Patients with LAV < 96.5 mL and ROAE ≥ 40% showed significantly higher arrhythmia-free rates (84% vs. 20%) after ablation.
  • A log-rank test indicated a statistically significant difference (p < 0.001).

Conclusions:

  • Smaller left atrial volume and a highly organized atrial electrogram pattern are associated with significantly lower atrial arrhythmia recurrence rates.
  • These findings suggest that LAV and ROAE can predict success after activation map-guided AF ablation.