Related Experiment Video
Updated: Jan 8, 2026
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
Cardiovascular damage and comorbidities related to long COVID: pathomechanisms, prevention, and therapy
Miroslava Kvandova1, Peter Balis1, Barbora Kalocayova2,3
1Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia.
Insights
Long COVID (LC) is a chronic condition following SARS-CoV-2 infection impacting multiple organ systems. This review explores cardiovascular mechanisms and potential micronutrient therapies for Long COVID.
Area of Science:
- Cardiology
- Infectious Diseases
- Nutritional Science
Background:
- Long COVID (LC) is a chronic condition associated with SARS-CoV-2 infection, persisting for over three months and affecting various organ systems, notably the cardiovascular system.
- Existing research indicates a link between SARS-CoV-2 infection and cardiovascular complications, with endothelial dysfunction emerging as a key pathogenic mechanism in both acute COVID-19 and LC.
- Despite progress in understanding LC's epidemiology and clinical course, its pathomechanisms remain incompletely understood, hindering the development of targeted therapies.
Purpose of the Study:
- To provide an up-to-date overview of the cardiovascular pathomechanisms implicated in Long COVID.
- To explore the potential role of micronutrients, vitamins, minerals, and flavonoids as preventive and therapeutic strategies for cardiovascular manifestations of LC.
Main Methods:
- This review is based on current literature.
- It synthesizes existing research on the cardiovascular sequelae of SARS-CoV-2 infection and LC.
- The review focuses on pathomechanisms and potential nutritional interventions.
Main Results:
- Endothelial dysfunction is a central pathomechanism in COVID-19 and a key factor in LC's cardiovascular impact.
- A comprehensive characterization of cardiovascular sequelae post-SARS-CoV-2 infection is still needed.
- Micronutrients, vitamins, minerals, and flavonoids are being investigated for their potential preventive and therapeutic roles.
Conclusions:
- Further research is essential to fully elucidate the pathomechanisms of cardiovascular Long COVID.
- Understanding these mechanisms is crucial for developing effective therapeutic and preventive strategies.
- Nutritional interventions, including micronutrients and flavonoids, show promise but require further investigation for LC management.
Abstract:
Long COVID (LC) is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-associated chronic condition and is present for at least 3 months as a continuous, relapsing and remitting, or progressive disease state that affects one or more organ systems, including cardiovascular. Extensive literature supports an association between SARS-CoV-2 infection and cardiovascular complications and increased cardiovascular risk after infection. The cardiovascular sequelae after SARS-CoV-2 infection have not yet been comprehensively characterized. A growing body of evidence suggests that endothelial dysfunction is a central mechanism in COVID-19 and has also been identified as a key pathogenic mechanism in LC. Although considerable progress has been made in characterizing the epidemiology, clinical course, and biology of LC, many questions remain unanswered. The incomplete understanding of the pathomechanisms of LC has hampered the development of targeted therapies to date. Further research and data are needed to develop effective therapeutic and preventive tools. Based on current literature this review aims to provide an up-to-date overview of the pathomechanisms affecting the cardiovascular system and the potential role of selected micronutrients, vitamins and minerals, and flavonoids as preventive and therapeutic strategies in LC.
More Related Videos
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
13:07Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:29Cardiomyopathy V: Interprofessional Care
01:30Cardiomyopathy II: Dilated Cardiomyopathy
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations