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Area of Science:

  • Supramolecular Chemistry
  • Coordination Chemistry
  • Materials Science

Background:

  • Biological systems exhibit remarkable functions due to conformational adaptability.
  • Mimicking this adaptability is key to developing advanced synthetic systems.
  • Coordination cages offer a versatile platform for exploring molecular behavior.

Purpose of the Study:

  • To investigate the role of conformational adaptability in designing low-symmetry coordination cages.
  • To explore the self-sorting behavior of cages with conformationally adaptive ligands.
  • To demonstrate control over cage properties like size, shape, and function.

Main Methods:

  • Assembly of cis-Pd2La2Lx2-type coordination cages using complementary ligands.
  • Utilizing a conformationally adaptable converging ligand (L-type) and rigid diverging ligands (Lx-type).
  • Employing integrative self-sorting experiments to analyze cage assembly and ligand adaptation.

Main Results:

  • The converging ligand adapted to three distinct conformations within the Pd2La2Lx2-type architecture.
  • Achieved 2-fold heteromeric competitive self-sorting, controlling ligand conformations in co-existing cages.
  • Demonstrated unprecedented 3-fold heteromeric competitive self-sorting, adapting three ligand conformations across three cages.

Conclusions:

  • Conformational adaptability is a powerful tool for designing sophisticated supramolecular systems.
  • This approach enables switchable size, shape, and functionality in coordination cages.
  • The findings pave the way for bio-relevant applications of adaptive supramolecular architectures.