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Updated: Jan 7, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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[Periodontitis Aggravates Chronic Obstructive Pulmonary Disease Progression by Promoting Pulmonary Macrophage M1

Jing Li1, Kaixin Xiong1, Boyu Tang1

  • 1（ 610041） State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|December 19, 2025
PubMed
Summary

Periodontitis worsens chronic obstructive pulmonary disease (COPD) by increasing M1 macrophage polarization in the lungs. Improving oral hygiene and inhibiting M1 polarization may offer new COPD treatment strategies.

Keywords:
Chronic obstructive pulmonary diseaseM1 polarizationMacrophagesPeriodontitis

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