Ginseng extract improves synaptic resiliency: A key factor for healthy cognitive aging
Michael F Almeida1,2,3,4, Morgan C Pait1, Katherine M Rentschler1
1Biotechnology Research and Training Center, University of North Carolina-Pembroke, Pembroke, North Carolina, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 19, 2025
Summary
Panax quinquefolius (PanQ) extract boosts the autophagy-lysosomal pathway (ALP) and cathepsin B (CatB), enhancing synaptic function and cognitive performance in aging rats.
Area of Science:
- Neuroscience
- Cell Biology
- Nutritional Science
Background:
- Autophagy-lysosomal pathway (ALP) disruption impairs proteostasis, contributing to age-related proteinopathies.
- Dietary interventions show promise in improving cognitive health and reducing Alzheimer's disease risk.
Purpose of the Study:
- To investigate the effects of plant-based extracts on the autophagy-lysosomal pathway (ALP) and cathepsin B (CatB) activity.
- To evaluate the potential of Panax quinquefolius (PanQ) extract in enhancing cognitive function and synaptic resilience in aging models.
Main Methods:
- Hippocampal explants were used to screen plant extracts for their ability to amplify cathepsin B (CatB).
- Panax quinquefolius (PanQ) extract was tested for its effects on synaptic proteins, autophagy markers (LC3-II), and cognitive performance in aging rats.
- Synaptic resilience was assessed in a lysosomal stress model.
Main Results:
- Panax quinquefolius (PanQ) extract significantly increased active cathepsin B (CatB) levels.
- PanQ treatment correlated with elevated synaptic protein levels and the autophagy marker LC3-II.
- PanQ enhanced synaptic resilience and improved cognitive performance in aged rats.
Conclusions:
- Panax quinquefolius (PanQ) enhances the autophagy-lysosomal pathway (ALP), implicating the proteostasis network in cognitive maintenance.
- Synaptic resilience is a key factor influenced by dietary components, impacting cognitive health.
- PanQ shows potential as a dietary intervention for age-related cognitive decline.
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