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Updated: Jan 8, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Synthetic methods for key precursors of biologically active dimethylsulfoxide ruthenium complexes
Sreshtha Nayek1, Rodrigo S Correa1,2, Ehsan Ezzatpour Ghadim1,3
1Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK. Ehsan.Ezzatpour-Ghadim.3@warwick.ac.uk.
Abstract:
Microwave- and sonication-assisted methods provide efficient synthesis of octahedral Ru(II) and Ru(III) S- and O-bound dimethyl sulfoxide (DMSO) complexes, precursors to anticancer, antimicrobial and anti-neurodegenerative drugs, in comparison with conventional hotplate (thermal) synthesis. In addition, sonication led to a novel O-bound DMSO oxo-bridged di-Ru(IV) complex, for which the X-ray structure, solvolysis, reduction by ferrocene, and Density Functional Theory (DFT) calculations are reported.
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