Ketamine Procedural Sedation in 38,910 Children: Frequency and Predictors of Critical and High-Risk Events
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View abstract on PubMed
Summary
This summary is machine-generated.Critical adverse events are rare in children receiving ketamine procedural sedation. Risk factors include upper respiratory infections with other sedatives and opioid co-administration.
Area Of Science
- Pediatric Anesthesiology
- Sedation Management
- Patient Safety
Background
- Ketamine is a common sedative for pediatric procedures.
- Understanding adverse events is crucial for safe ketamine use.
- Data on critical adverse events is limited.
Purpose Of The Study
- Assess the frequency of critical/high-risk adverse events with ketamine as primary sedative.
- Identify clinical predictors of these adverse events in children.
Main Methods
- Retrospective analysis of a prospective registry.
- Included 38,910 children receiving ketamine for procedural sedation.
- Data collected from 84 institutions across various settings.
Main Results
- 15 critical adverse events (0.04%) occurred, including cardiac arrest, aspiration, and intubation.
- No deaths or permanent adverse outcomes reported.
- Upper respiratory infection with benzodiazepines/dexmedetomidine and opioid use were key risk factors.
Conclusions
- Critical adverse events are rare when ketamine is used as a primary procedural sedative.
- Risk factors identified include URIs with co-sedatives and opioid administration.
- Findings support safe ketamine administration protocols.
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