Related Experiment Video
Updated: Jan 8, 2026
07:51
Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
860
Progressive pulmonary fibrosis
Ramey Bajwa1, Drew Lancaster2, Sujal R Desai3,4
1Department of Interstitial Lung Disease, Royal Brompton Hospital, London, UK. rameybajwa@gmail.com.
European Radiology
|December 19, 2025
Summary
Progressive pulmonary fibrosis (PPF) mimics idiopathic pulmonary fibrosis (IPF) and increases mortality. Identifying radiological progression on CT scans is crucial for timely antifibrotic treatment and slowing lung function decline.
Area of Science:
- Pulmonology
- Radiology
- Medical Imaging
Background:
- A subset of non-idiopathic pulmonary fibrosis (IPF) cases exhibit a progressive pulmonary fibrosis (PPF) trajectory.
- PPF is linked to heightened patient mortality and mimics IPF clinically.
- Identifying PPF is critical for patient management and prognosis.
Purpose of the Study:
- To define radiological progression criteria for identifying PPF.
- To highlight the role of radiologists in managing PPF patients.
- To underscore the importance of early detection for antifibrotic therapy.
Main Methods:
- Analysis of serial high-resolution computed tomography (CT) scans.
- Evaluation of fibrosis extent and severity changes over time.
- Radiological assessment for progression in non-IPF cases.
Main Results:
- Radiological progression in PPF is characterized by increased overall fibrosis extent.
- Progression can also manifest as increased fibrosis severity with unchanged overall extent.
- Accurate radiological identification enables timely intervention.
Conclusions:
- Radiologists are pivotal in diagnosing PPF through CT assessment.
- Identifying radiological progression allows for initiation of antifibrotic drugs.
- Early antifibrotic treatment can significantly mitigate lung function decline in PPF.
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