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Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Pulmonary Hypertension: Classification and Pathogenesis

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Chronic Obstructive Pulmonary Disease

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Related Experiment Video

Updated: Jan 8, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Progressive pulmonary fibrosis.

Ramey Bajwa¹, Drew Lancaster², Sujal R Desai^3,4

¹Department of Interstitial Lung Disease, Royal Brompton Hospital, London, UK. rameybajwa@gmail.com.

European Radiology

|December 19, 2025

Summary

This summary is machine-generated.

Progressive pulmonary fibrosis (PPF) mimics idiopathic pulmonary fibrosis (IPF) and increases mortality. Identifying radiological progression on CT scans is crucial for timely antifibrotic treatment and slowing lung function decline.

Keywords:

Antifibrotics Computed tomography Nintedanib Progressive pulmonary fibrosis Radiological progression of fibrosis

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Area of Science:

Pulmonology
Radiology
Medical Imaging

Background:

A subset of non-idiopathic pulmonary fibrosis (IPF) cases exhibit a progressive pulmonary fibrosis (PPF) trajectory.
PPF is linked to heightened patient mortality and mimics IPF clinically.
Identifying PPF is critical for patient management and prognosis.

Purpose of the Study:

To define radiological progression criteria for identifying PPF.
To highlight the role of radiologists in managing PPF patients.
To underscore the importance of early detection for antifibrotic therapy.

Main Methods:

Analysis of serial high-resolution computed tomography (CT) scans.
Evaluation of fibrosis extent and severity changes over time.
Radiological assessment for progression in non-IPF cases.

Main Results:

Radiological progression in PPF is characterized by increased overall fibrosis extent.
Progression can also manifest as increased fibrosis severity with unchanged overall extent.
Accurate radiological identification enables timely intervention.

Conclusions:

Radiologists are pivotal in diagnosing PPF through CT assessment.
Identifying radiological progression allows for initiation of antifibrotic drugs.
Early antifibrotic treatment can significantly mitigate lung function decline in PPF.