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Updated: Jan 8, 2026
Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Tumor budding in gastric adenocarcinoma: prognostic value and association with clinicopathological markers
Dhouha Bacha1, Neirouz Kammoun2, Bilel Troudi1
1Mongi Slim Hospital, Pathology Department - Marsa, Tunis, Tunisia.
Background:
The analysis of tumor budding (TB) and its prognostic value in gastric adenocarcinoma (GA) has been the focus of several studies, with inconsistent results. This parameter is not included in gastric prognostic classifications or standardized pathological reports.
Aims:
To evaluate TB in GA and its prognostic significance through survival analysis, in addition to investigating the association between TB and clinicopathological markers that are considered prognostic factors for this type of cancer.
Methods:
This retrospective study covers a period of ten years, from January 2008 to December 2017. It included patients who underwent surgery for GA. TB evaluation followed the 2016 consensus guidelines for colorectal cancer, with three grades: Bd1 (0-4 buds), Bd2 (5-9 buds), and Bd3 (10 or more buds). Additionally, a two-grade classification system was employed, distinguishing between low-grade budding (fewer than 10 buds) and high-grade budding (10 or more buds).
Results:
TB was classified as low-grade in 69% of the cases and high-grade in 31%. High-grade TB was significantly correlated with perineural invasion (HR [hazard ratio]: 2.98, 95%CI [95% confidence interval] 1.04-8.53, p=0.004), stages III and IV (HR 4.04, 95%CI 1.27-12.83, p=0.01), and mortality (HR 3.65, 95%CI 1.24-10.74, p=0.02). It was an independent prognostic factor for recurrence-free survival (RFS) (p=0.005, p<0.05).
Conclusions:
We have demonstrated that TB prognostic and predictive value in GA is significant, particularly regarding patient survival.
