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Published on: November 14, 2020
Preoperative glycemic response to a very low-calorie diet predicts long-term type 2 diabetes remission after
Mariana Fior Frias Thomaz Bortolan1, Roberto DE Cleva2, Leandro Ferreira2
1Universidade de São Paulo, Faculty of Medicine, Science Program in Gastroenterology - São Paulo (SP), Brazil.
Background:
Obesity and type 2 diabetes mellitus are highly prevalent conditions with a significant public health impact, highlighting the need for effective management strategies. Bariatric surgery is widely recognized for promoting sustained weight loss and high rates of type 2 diabetes mellitus remission.
Aims:
This study investigated the preoperative blood glucose response to a very low-calorie diet as a functional predictor of type 2 diabetes mellitus remission following Roux-en-Y gastric bypass.
Methods:
198 participants who followed a very low-calorie diet (600 kcal/day) during the preoperative period were included, with glycemic response monitoring.
Results:
Complete remission of type 2 diabetes mellitus occurred in 66.7% of patients. Two years after surgery, patients with blood glucose levels below 143 mg/dL on the second day of the very low-calorie diet had a higher likelihood (over 70%) of achieving complete remission type 2 diabetes mellitus in the late postoperative period.
Conclusions:
Preoperative capillary blood glucose levels demonstrated good specificity in predicting remissions. These findings reinforce the clinical utility of early glycemic control as a valuable indicator for predicting the success of surgical treatment for type 2 diabetes mellitus.
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