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Evaluation of Enterococcus faecium EF137v on colorectal carcinogenesis
Priscilla Régia A Calaça1, Dayane S Santos2, Janaína F DA Silva1
1Universidade Federal Rural de Pernambuco, Departamento de Morfologia e Fisiologia Animal, Dom Manuel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil.
Anais Da Academia Brasileira De Ciencias
|December 19, 2025
Summary
Enterococcus faecium 137v (EF137v) probiotic administration protected against colorectal cancer (CRC) in rats by preserving intestinal mucosa and reducing inflammation. EF137v also demonstrated hepatoprotective effects, preventing liver inflammation in this animal model.
Area of Science:
- Gastroenterology
- Oncology
- Microbiology
Background:
- Probiotics, like Enterococcus faecium, are crucial for gastrointestinal homeostasis.
- Enterococcus faecium is a potential candidate for preventing colorectal cancer (CRC).
Purpose of the Study:
- To assess the protective effects of Enterococcus faecium 137v (EF137v) against chemically induced colorectal carcinogenesis.
- To evaluate the hepatoprotective activity of EF137v in a colorectal cancer animal model.
Main Methods:
- Oral administration of EF137v to female Wistar rats treated with 1,2-dimethylhydrazine (DMH).
- Analysis included biochemical assays, histopathology, histochemistry, immunohistochemistry (VEGF-A, IL-1β, TNF-α), morphometry, and apoptosis assessment.
Main Results:
- EF137v administration preserved intestinal mucosa and attenuated apoptosis.
- Reduced formation of aberrant crypts and inflammation was observed.
- EF137v treatment prevented liver inflammation, unlike the DMH-only control group which showed low glycogen levels.
Conclusions:
- EF137v exhibits a preventive effect against preneoplastic lesions in colorectal carcinogenesis.
- EF137v reduces and inhibits inflammation and aberrant crypt formation.
- EF137v demonstrates significant hepatoprotective activity in an animal model.
