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Related Experiment Video

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A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
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Silicone Oil Removal Related Vision Loss: Questioning Different Outcomes.

Maria Ludovica Ruggeri1,2, Alberto Quarta3, Tommaso Verdina4

  • 1Retina Division, Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland, USA, marialudovica.ruggeri@gmail.com.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|December 19, 2025
PubMed
Summary

Silicone oil removal-related vision loss (SORVL) is a rare complication after eye surgery. This case series shows varied outcomes, including rare complete recovery, highlighting the condition's heterogeneity.

Keywords:
Ganglion cellsGiant tearNerve fiber layerOptical coherence tomographyRhegmatogenous retinal detachmentSilicone oil

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Area of Science:

  • Ophthalmology
  • Retinal Surgery
  • Vision Science

Background:

  • Silicone oil removal-related vision loss (SORVL) is a rare but serious complication following silicone oil removal (ROSO) surgery.
  • The disease spectrum and underlying pathophysiology of SORVL remain largely unknown.
  • Existing literature predominantly describes SORVL as unrecoverable.

Purpose of the Study:

  • To retrospectively analyze clinical outcomes in six cases of SORVL.
  • To describe patient characteristics, clinical presentation, and disease course.
  • To explore potential hypotheses regarding the pathophysiology of SORVL.

Main Methods:

  • Retrospective case series of six patients diagnosed with SORVL.
  • Analysis of clinical characteristics at presentation and during follow-up.
  • Documentation of treatment responses and visual outcomes.

Main Results:

  • The majority of patients (83%) were male and underwent ROSO after retinal detachment (RD) surgery with pars plana vitrectomy (PPV).
  • Significant visual improvement occurred in two cases (33.3%).
  • Complete visual recovery was observed in one case (16.6%), a rare outcome for SORVL.

Conclusions:

  • This case series demonstrates significant heterogeneity in clinical outcomes for SORVL.
  • Despite shared initial symptoms, patient outcomes varied considerably.
  • Further research is crucial to elucidate the pathophysiology and identify factors influencing SORVL prognosis.