Electroacupuncture suppresses premature ventricular complexes occurring post-myocardial infarction through
Fan Zhang1, Qian-Yi Wang2, Nai-Xuan Wei2
1College of Acupuncture and Moxibustion, Institute of Acupuncture and Meridian Research, Anhui University of Chinese Medicine, Hefei 230038, Anhui Province, China; Anhui Province Key Laboratory of Meridian Viscera Correlationship, Hefei 230038, Anhui Province, China; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine, Insitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei 230601, China.
None:
Electroacupuncture (EA) has been shown to suppress premature ventricular complexes (PVCs) following myocardial infarction (MI) in humans. However, the specific neural circuitry and causal mechanisms underlying this effect remain unclear. Here, we reveal a connection from the primary motor cortex to the nucleus rostral ventrolateral medulla (RVLM) circuitry via the layer 5 of the primary motor cortex (M1L5)-zona incerta (ZI)-RVLM pathway, which suppresses PVCs in post-MI male mice. Utilizing viral tracing, fiber photometry recordings, and optogenetic stimulation, we demonstrate that EA treatment normalizes the abnormal hyperexcitability of glutamatergic neurons in the M1L5 region after MI, thereby reducing the occurrence of post-MI PVCs in mice via the M1L5-ZI-RVLM neural circuit. Overall, our findings highlight the M1L5-ZI-RVLM circuit as a crucial mediator of EA-induced suppression of PVCs following MI. Additionally, this corticothalamic circuit may represent a promising target for mitigating PVCs post-MI.
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