Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Infants and Children

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Parental Perceptions on Antenatal Information About Extremely Preterm Birth: A Qualitative Study.

Acta paediatrica (Oslo, Norway : 1992)·2026

Same author

Lymphocyte transformation test in pediatric drug hypersensitivity: case series report from a tertiary care hospital.

Frontiers in immunology·2026

Same author

Rupture of membranes and short-term respiratory outcomes in extremely preterm infants: a multicenter retrospective cohort study.

Pediatric research·2026

Same author

The ESINEA Study: A Novel Screening Tool for Identifying Patient Safety Incidents and Adverse Events in Hospitalized Patients-An Index-Date Cohort Evaluation.

Therapeutics and clinical risk management·2026

Same author

Baseline immune status associates respiratory viral infection in preterm infants: A prospective cohort study.

Medicine·2026

Same author

Gorm Greisen and the transformation of our understanding of newborn brain physiology: a tribute on the occasion of his retirement, on behalf of the ESPR NIRS Special Interest Group.

Pediatric research·2026

Search research articles

Related Experiment Video

Updated: Jan 8, 2026

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Dose-finding for dobutamine during transitional circulation in the very preterm infant: The study protocol.

Maria Sanchez-Holgado¹, Patricia Alvarez-Garcia¹, Maria Carmen Bravo¹

¹Department of Neonatology, La Paz University Hospital, Hospital La Paz Institute for Health Research-IdIPAZ, Madrid, Spain.

|December 19, 2025

Summary

This study seeks the optimal dobutamine dose for preterm infants with circulatory issues. It aims to find the minimum effective dose to improve blood flow and reduce risks in vulnerable newborns.

More Related Videos

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Related Experiment Videos

Last Updated: Jan 8, 2026

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Area of Science:

Neonatal physiology and pharmacology
Cardiovascular research in neonates
Clinical trial design in vulnerable populations

Background:

Hemodynamic insufficiency in preterm infants can lead to poor outcomes.
Superior vena cava (SVC) flow is a potential biomarker for circulatory impairment.
Dobutamine is a potential treatment, but optimal dosing in preterm infants is unknown.

Purpose of the Study:

To determine the minimum effective dose of dobutamine for treating hemodynamic insufficiency in preterm infants.
To assess the pharmacokinetic/pharmacodynamic (PK/PD) profile of dobutamine in this population.
To lay the groundwork for future efficacy and safety trials of dobutamine.

Main Methods:

A multicenter, dose-finding trial in preterm infants (≤32 weeks gestation) with hemodynamic insufficiency (SVC flow <51 mL/kg/min).
Participants will be allocated to dobutamine dosage regimens based on therapeutic response.
Echocardiography and PK/PD assessments will be performed to evaluate circulatory status and drug behavior.

Main Results:

The study aims to identify the minimum dobutamine dose with a significant pharmacodynamic effect on transitional circulation.
It will explore the proportion of infants achieving adequate hemodynamics and identify factors influencing PK/PD variability.
This research will provide crucial data on dobutamine's effects in preterm infants.

Conclusions:

This trial will establish the minimum effective dobutamine dose for hemodynamic insufficiency in preterm infants.
It represents a critical first step towards future randomized clinical trials.
The findings will inform the optimal use of dobutamine in neonatal intensive care settings.