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Bridging Radiology and Pathology: ATRX Loss and T2-FLAIR Mismatch as Early Diagnostic and Prognostic Markers in
Quratulain Tariq1, Eisha Abid Ali2, Rahamah Arshad2
1Department of Neurosurgery, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Abstract:
ATRX mutation and the T2-FLAIR mismatch sign have emerged as complementary molecular and imaging markers in diffuse gliomas. ATRX loss defines IDH-mutant astrocytoma at the molecular level, while the mismatch sign provides a non-invasive radiological clue with high specificity but limited sensitivity. Used together, they improve diagnostic precision, refine prognostic assessment, and guide individualized treatment planning.
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