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Pseudofracture: An Acute Peripheral Tissue Trauma Model
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Pseudofracture: An Acute Peripheral Tissue Trauma Model

Published on: April 18, 2011

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Fibrinogen as an early predictor of acute organ dysfunction in pelvic fractures

Po-Chun Wang1, Kuo-En Chen1, Hui-An Lin2

  • 1School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Injury
|December 19, 2025
PubMed

Insights

Low fibrinogen levels (≤200 mg/dL) in pelvic fracture patients predict higher mortality and organ dysfunction. This finding highlights fibrinogen as a critical prognostic marker in trauma care.

Area of Science:

  • Trauma Surgery
  • Hematology
  • Critical Care Medicine

Background:

  • Pelvic fractures are linked to significant morbidity and mortality.
  • The prognostic implications of initial fibrinogen levels in these patients are not well understood.

Purpose of the Study:

  • To investigate the prognostic value of initial fibrinogen levels in patients with pelvic fractures.
  • To determine the association between low fibrinogen levels and adverse outcomes, including mortality and organ dysfunction.

Main Methods:

  • Global retrospective cohort study using TriNetX Global Collaborative Network data (2005-2025).
  • Included patients with pelvic fractures and available fibrinogen levels, with ≥30 days follow-up.
  • Propensity score matching adjusted for covariates; compared outcomes for fibrinogen ≤200 mg/dL vs. >200.01 mg/dL.

Main Results:

  • 10,552 matched patients analyzed; low fibrinogen group showed significantly higher 30-day risks.
  • Increased risks observed for acute kidney injury (RR 1.30), shock (RR 1.51), respiratory failure (RR 1.29), ARDS (RR 1.28), DIC (RR 2.06), and all-cause mortality (RR 1.90).
  • Associations remained consistent across subgroups and sensitivity analyses.

Conclusions:

  • Fibrinogen level ≤200 mg/dL is a significant predictor of increased mortality.
  • Low fibrinogen is associated with heightened risk of acute organ dysfunction in pelvic fracture patients.
Abstract

Keywords:
Acute kidney injuryAcute organ dysfunctionDisseminated intravascular coagulationFibrinogenMultiple organ failurePelvic fractureRespiratory distress syndrome

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